Health information systems can help make our healthcare systems economically sustainable. The recent EHR IMPACT study shows the importance of interoperability in this quest, as well as what needs to be in place in order to realise the potential. Following the positive resonance to the EHR IMPACT final report, the European Commission (EC) is now publishing the results in a stand-alone publication. “Interoperable eHealth is Worth it - Securing Benefits from Electronic Health Records and ePrescribing” provides insights into the real socio-economic and financial impact of eHealth. The empirical evidence is based on eleven case studies from across Europe and beyond – Scotland, Kronoberg in Sweden, Kolín-Čáslav in the Czech Republic, Geneva Switzerland, Lombary in Italy, Rhône-Alpes in France, Bulgaria, Andalusia in Spain, Israel, and Evanston in the USA. A sneak-preview of the new publication will be available at the EC booth n°801 at the joint Ministerial eHealth conference and World of Health IT conference and exhibition.